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KMID : 0043320190420110977
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Archives of Pharmacal Research
2019 Volume.42 No. 11 p.977 ~ p.989
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Synthesis of arbutin?gold nanoparticle complexes and their enhanced performance for whitening
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Park Jin-Ju
Hwang Su-Jung
Kang Yu-Sun
Jung Ji-Sung
Park Su-Ryeon
Hong Jee-Eun
Park Yo-Han
Lee Hyo-Jong
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Abstract
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Arbutin, a natural polyphenol, possesses numerous biological activities including whitening, anti-oxidant, anti-cancer, anti-inflammatory activities, as well as strong reducing power, making it an ideal bioactive ingredient for preparing gold nanoparticles (GNPs). Previously, we developed a novel green, mild synthetic method for GNPs using glycosides such as arbutin as reducing agents and stabilizers. Herein, we optimized the synthetic method for glycoside?GNPs using arbutin, methyl β-d-glucoside, and phenyl β-d-glucoside and validated their whitening efficacy in vitro and in vivo. The resulting glycoside?GNPs were predominantly mono-dispersed and spherical (10.30?17.13 nm diameter). Compared with arbutin itself, arbutin?GNP complexes (GNP-A1 and GNP-P2) displayed enhanced whitening capabilities. Furthermore, GNP-P2 exhibited enhanced anti-inflammatory activity and lacked the toxicity associated with arbutin. Bioactive glycoside?GNP complexes may open new directions for cosmeceuticals, and GNP-P2 may serve as a useful whitening ingredient in future cosmeceutical applications.
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KEYWORD
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Arbutin?gold nanoparticles, Whitening, Polyphenolic compounds, Glycoside?GNPs, Anti-inflammatory activity, Cosmeceuticals
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